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To learn more about our gynecologist and obstetric services or to schedule an appointment, please call our main office at Are You Having Ovulation Difficulty? What are some menstrual or blood testing clues that can indicate you are a Letrozole candidate? If your periods are very irregular.
If you rarely or never have a period. If your periods are regular but your progesterone levels are low. Letrozole May Be The Right Treatment For You First, before deciding if Letrozole might be an option, we will need you to have your blood tested so we can exclude some medical issues.
You will be tested for: your thyroid levels, your prolactin levels, and any sign of diabetes or pre-diabetes. How Does Letrozole Work?
And, if you prefer to try Clomid, we will honor your choice. Lastly, Are There Any Risks? The impact of Letrozole on fertility has been widely studied. Letrozole helps to improve fertility in two main ways, 1 inducing ovulation and 2 increasing the number of eggs released each cycle.
Letrozole encourages the ovaries to ovulate by producing more natural stimulation. Letrozole improves ovulation by blocking estrogen production, which causes the body to release higher than normal levels of follicle-stimulating hormone FSH. The additional levels of FSH stimulate ovarian follicle s to develop and mature in the ovary. For women without ovulatory issues, Letrozole can cause them to develop multiple mature follicles, which release more than one eggs for ovulation.
Letrozole can increase the number of eggs released each cycle by increasing the number of follicles that develop. In a normal ovulatory cycle, one follicle develops, and one egg is released. In a Letrozole medicated cycle, the amount of FSH a woman produces increases which may cause multiple follicles to develop and multiple eggs to be released, especially for women who ovulate regularly.
The release of multiple eggs gives a better chance for fertilization to occur. Medicated cycles that result in the development of multiple follicles and eggs are referred to as controlled ovarian stimulation cycles. Aromatase is an enzyme that is responsible for a vital step in the production of estrogen. Femara Letrozole is an aromatase inhibitor. By inhibiting the function of aromatase, Letrozole suppresses the production of estrogen.
When there is less estrogen, the pituitary gland produces additional levels of follicle-stimulating hormone FSH and Luteinizing Hormone LH. The increased production of FSH and LH causes improved development, maturation, and ovulation of one or more egg.
As such, it makes sense that a large portion of Letrozole research is conducted on patients with Polycystic Ovarian Syndrome. Clomid has historically been used as the first-line fertility treatment for PCOS patients with ovulatory issues. However, recent research suggests that Letrozole may produce similar, if not better, results for inducing ovulation and producing live births for PCOS patients. During the study, women received Letrozole treatment, and women received Clomiphene treatment for five days starting on day three of their cycle for up to 5 cycles.
Of the women treated with Letrozole, Of the women treated with Clomiphene, only 72 Not only was the live birth rate higher for the Letrozole group, but so was their cumulative ovulation rate. The women in the Letrozole group had a cumulative ovulation rate of The women in the clomiphene group ovulated Although Letrozole can cause women to produce multiple eggs, the result is not as common in women with PCOS or other ovulatory disorders. Patients with PCOS are commonly hyper-responsive to gonadotropin drugs.
Letrozole can cause PCOS patients to develop and ovulate an egg while keeping them at a lower risk for hyper-stimulation, which could be caused by other fertility medications. Recent studies have shown that Letrozole can be beneficial in treating unexplained infertility. In one study, researchers measured the effects of Clomiphene and Letrozole treatment on improving pregnancy rate, miscarriage rate, incidence rate of adverse events, and the number of dominant follicles for patients with unexplained infertility.
The results of the study showed that women treated with Letrozole displayed a significantly higher rate of clinical pregnancy as compared to those treated with Clomiphene. There was no statistical difference between the groups for the other fertility outcomes. Researchers concluded that Letrozole is at least as effective as Clomiphene for treating women with unexplained infertility.
Researchers compared the efficacy of Letrozole and Clomiphene treatment on women with unexplained infertility in a randomized control trial. More than double the percentage of women treated with Letrozole achieved pregnancy
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